Prior to the start of the series, the band members were all having their own little adventures and problems in life. Ray was one of the earliest of band members as he was already playing in The Ozzys back during High School as his first band. he quit the band after thinking that his father would return but he didn't and so he fled to the Main Town. Ray would become the first member of the band starting out as a lone drummer until Vince showed up. Once Vince showed up, the two of them had started the band and eventually Alec showed up and the Lyosacks were born. They had their first concert in the backyard of the Evil Dr. Yequil who wanted do destroy them but they got away. However, they are now slacking off in the apartment with adventure and dramas.
Soon they got in trouble with the Morrentinis and in the first timeline, they are disbanded as Vince died and Alec and Ray lost contact until 20 years when they decide to fix the timeline with the help of Tommy Robot. They managed to fix the timeline with the Morrentinis eliminated and continue their lives. Little to they know, Ray only teleport them to the Arctic where they intercept Albert and capture the bomb. Alec and the brothers told their story to Vince, Ray and Emmy and realize that their town is targeted as a testing ground for the bomb. As they tried to escaped, Ray met his father incidentally and delaying the bomb countdown. Despite Ryan change of heart, the bomb nevertheless detonated and the town lies in ruins. The Lyosacks later worked together to stop the Morrentinis from starting an apocalypse. However, their apartment lies in ruins and they decide to find a new home, Vince stole an RV and together with Emmy, they drive to their adventure. They have face Slenderman, having Battle of the Bands, facing Freddy Pizzeria, discuss about their existence as animation and having a triple date
At the Coastal Town, Yequil calls the Lyosacks to help to stop Robo Yequil No 1 and ask to return back to the Main Town. They arrived back but they faced trouble as Ray is forced to stay behind to clean up and both Vince and Emmy are grounded, leaving Alec for the task. Although Alec managed to stop the robot, the robot convinced Alec to change the past, leaving Ray, Yequil and Robo Yequil No 2 to deal with the situation. Although, the situation is defused, the band split up when Vince had to go to the hospital to meet his radioactive sicken father, Alec to find his older brother where he thought he was dead and Ray dealing his own situation against Slenderman.